Why the study?
Does aliskiren improve systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression?
Population
Young (aged 6-9 wk) transgenic TG(mRen2)27 rats (Ren2) and age-matched Sprague Dawley control rats
Comparison
Aliskiren 50 mg/kg/day intraperitoneally for 21… vs Placebo for 21 days
Design
Preclinical
Follow-up
21 days
Authors
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Should not yet change clinical practice; hypothesis-generating for renin inhibition in insulin resistance.
Does aliskiren improve systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression?
In a transgenic rat model of tissue renin overexpression, renin inhibition with aliskiren improved systemic insulin sensitivity and skeletal muscle glucose transport while reducing oxidative stress and fibrosis.
Lastra et al. (2009) studied this question.
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