Why the study?
Is sympathetic nerve activity (plasma noradrenaline) altered in mild essential hypertension compared to normotensive controls?
Is sympathetic nerve activity (plasma noradrenaline) altered in mild essential hypertension compared to normotensive controls?
Sympathetic nerve activity, as measured by plasma noradrenaline, is normal in mild essential hypertension when compared to appropriately matched normotensive controls.
Sympathetic activity appears normal in mild essential hypertension; leaves open renin-noradrenaline coupling and requires prospective validation before clinical consideration.
Forty-year-old individuals with mild essential hypertension, identified during a survey of a population born in 1936, were investigated. Forty-year-old normotensive subjects, drawn from the same population, served as a control group. 2. Plasma noradrenaline concentration and plasma renin concentration at rest supine and after acute stimulation, as induced by frusemide intravenously and ambulation, did not differ from reference values in the 40-year-old normotensive controls. In the hypertensive group a close correlation (r = 0.77, P less than 0.001) was found between plasma noradrenaline and plasma renin concentration after acute stimulation. 3. Sympathetic nerve activity, as defined by measurements of plasma noradrenaline, is normal in mild essential hypertension. Discrepancies described in the literature are probably related to a lack of comparability between hypertensive and normotensive study populations.
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Ibsen et al. (1979) studied this question.
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