Key result
Six-month post-ablation AF burden below 50% is linked to ~67% lower mortality and HF risk.
Why the study?
The impact of atrial fibrillation recurrence and atrial fibrillation burden after ablation on long-term treatment benefit in patients with heart failure remains unknown.
Does achieving an AF burden below 50% after catheter ablation improve mortality and HF outcomes in patients with coexisting HF and AF?
RCT (n=280)
randomized
Yes
Does achieving an AF burden below 50% after catheter ablation improve mortality and HF outcomes in patients with coexisting HF and AF?
Hazard Ratio: 0.33 (95% CI 0.15–0.71)
p-value: p=0.014
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Achieving an AF burden <50% at 6 months post-ablation, rather than freedom from any AF recurrence, predicts improved hard clinical outcomes in patients with HFrEF.
Brachmann et al. (2021) conducted an RCT in Heart failure with atrial fibrillation (n=280). Catheter ablation vs. Pharmacological therapy was evaluated on Primary composite outcome (mortality and occurrence of HF) (HR 0.33, 95% CI 0.15-0.71, p=0.014). An atrial fibrillation burden below 50% at 6 months after catheter ablation significantly reduced the primary composite outcome of mortality and heart failure (HR 0.33; 95% CI 0.15-0.71; p=0.014).
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