Key result
The H11-H12 loop in the globular tail domain and the IQ1 motif in the head dictate the isoform-specific interactions that regulate the tail inhibition mechanism of class V myosin.
The study identifies that the H11-H12 loop in the globular tail domain and the IQ1 motif in the head dictate isoform-specific interactions regulating class V myosin motor function.
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Supports conserved tail inhibition in Myo5c; leaves open Ca2+-dependent cargo roles in vertebrate cells.
Yao et al. (2016) studied this question. Myo5 chimeras vs. Wild-type Myo5 isoforms was evaluated on ATPase activity and motor function inhibition. The H11-H12 loop in the globular tail domain and the IQ1 motif in the head dictate the isoform-specific interactions that regulate the tail inhibition mechanism of class V myosin.
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