Population
Mammalian myosin Va constructs (full-length, GTD-deleted, and various truncated constructs)
Comparison
Addition of exogenous globular tail domain and… vs Full-length myosin Va, GTD-deleted myosin Va…
Design
Preclinical
Authors
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Supports GTD autoinhibition of myosin Va; leaves open relevance to cardiac myosins or human disease.
The globular tail domain of myosin Va functions as an inhibitor of the motor by binding to the C-terminal end of coil-1, stabilizing a triangular inhibited conformation.
Li et al. (2006) studied this question.
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