Population
In vitro purified full-length mouse melanocyte-type myosin Va, myosin Va heavy meromyosin, and GST-GTD…
Comparison
Alanine mutations of conserved charged residues vs Wild-type (WT) myosin Va proteins
Design
Preclinical
Authors
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Clarifies myosin Va autoinhibition mechanism; extends structural models but leaves open relevance to human cardiac disease.
The study identifies specific conserved residues (Asp-136, Lys-1706, Lys-1779) critical for the tail-inhibition mechanism of the myosin Va motor protein.
Li et al. (2008) studied this question.
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