Key result
Resveratrol administration ameliorated maternal and post-weaning high-fat diet-induced nonalcoholic fatty liver disease in rat offspring by regulating lipid metabolism, reducing oxidative stress, and modulating the renin-angiotensin system.
Why the study?
Does resveratrol improve maternal and post-weaning high-fat diet-induced NAFLD in Sprague-Dawley rats?
Does resveratrol improve maternal and post-weaning high-fat diet-induced NAFLD in Sprague-Dawley rats?
Resveratrol ameliorates maternal and postnatal high-fat diet-induced NAFLD in rats by reducing oxidative stress, apoptosis, and modulating the renin-angiotensin system.
Resveratrol prevented HF-induced NAFLD in rat offspring; leaves open translation to human prevention strategies.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) can develop in prenatal stages and can be exacerbated by exposure to a postnatal high-fat (HF) diet. We investigated the protective effects of resveratrol on prenatal and postnatal HF diet-induced NAFLD. METHODS: Male Sprague-Dawley rat offspring were placed in five experimental groups (n = 10-12 per group): normal diet (VNF), maternal HF diet (ONF), postnatal HF diet (VHF), and maternal HF diet/postnatal HF diet (OHF). A therapeutic group with resveratrol for maternal HF diet/postnatal HF diet (OHFR) was used for comparison. Resveratrol (50 mg/kg/day) was dissolved in drinking water for offspring from post-weaning to postnatal day (PND) 120. RESULTS: We found that HF/HF-induced NAFLD was prevented in adult offspring by the administration of resveratrol. Resveratrol administration mediated a protective effect on rats on HF/HF by regulating lipid metabolism, reducing oxidative stress and apoptosis, restoring nutrient-sensing pathways by increasing Sirt1 and leptin expression, and mediating the renin-angiotensin system (RAS) to decrease angiotensinogen, renin, ACE1, and AT1R levels and increased ACE2, AT2R and MAS1 levels compared to those in the OHF group. CONCLUSION: Our results suggest that a maternal and post-weaning HF diet increases liver steatosis and apoptosis via the RAS. Resveratrol might serve as a therapeutic target by mediating protective actions against NAFLD in offspring exposed to a combination of maternal and postnatal HF diet.
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Tiao et al. (2018) studied Nonalcoholic fatty liver disease (NAFLD). Resveratrol vs. Maternal and postnatal high-fat diet without resveratrol was evaluated on Hepatic lipid accumulation and metabolic parameters (p=<0.05). Resveratrol administration ameliorated maternal and post-weaning high-fat diet-induced nonalcoholic fatty liver disease in rat offspring by regulating lipid metabolism, reducing oxidative stress, and modulating the renin-angiotensin system.
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