Population
Isolated guinea pig hearts
Comparison
Global ischemia at 37 degrees C followed by… vs Nonischemic control hearts, hearts subjected to…
Design
Preclinical
Authors
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Hypothesis-generating for cytoskeletal preservation in myocardial stunning; leaves open whether protease inhibition improves recovery in vivo.
Contractile dysfunction in stunned myocardium correlates with the disappearance of cytoskeletal proteins, likely mediated by Ca2+-dependent intracellular proteases activated during reperfusion.
Matsumura et al. (1996) studied this question.
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