Why the study?
Does leupeptin improve recovery of developed pressure in isolated guinea pig hearts subjected to global ischemia and reperfusion?
Population
Isolated guinea pig hearts subjected to global ischemia (15 min, 37 degrees C) and reperfusion (n=36)
Comparison
Leupeptin 50 microM vs Untreated hearts and nonischemic control
Design
Preclinical
Authors
Loading...
Should not change clinical practice; hypothesis-generating for protease inhibition in ischemia-reperfusion injury.
Does leupeptin improve recovery of developed pressure in isolated guinea pig hearts subjected to global ischemia and reperfusion?
Leupeptin protects against myocardial stunning in isolated guinea pig hearts, suggesting protease activation by Ca2+ overload plays a significant role in post-ischemic contractile dysfunction.
Matsumura et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: