Key result
Pioglitazone induced regression of carotid intima-media thickness in Japanese patients with type 2 diabetes, though the difference compared to control did not reach statistical significance.
Why the study?
Does pioglitazone reduce the progression of carotid intima-media thickness in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity?
RCT (n=186)
Open-label, blinded endpoint
Dynamic allocation
Yes
Does pioglitazone reduce the progression of carotid intima-media thickness in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity?
Absolute Event Rate: -0.069% vs -0.031%
p-value: p=NS
In Japanese patients with type 2 diabetes, pioglitazone induced regression of carotid IMT from baseline, though the difference compared to other oral glucose-lowering drugs was not statistically significant.
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Pioglitazone shows no significant advantage over controls for carotid IMT regression; leaves open its role in attenuating atherosclerosis in Japanese T2D.
Yamasaki et al. (2010) conducted an RCT in Type 2 diabetes (n=186). Pioglitazone vs. Oral glucose-lowering drugs excluding thiazolidinediones was evaluated on Absolute change from baseline to final visit in max-IMT of bilateral common carotid arteries (p=NS). Pioglitazone induced regression of carotid intima-media thickness in Japanese patients with type 2 diabetes, though the difference compared to control did not reach statistical significance.
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