Population
Leishmania major (DHFR-TS locus) and artificial pre-RNAs expressed in vivo
Comparison
Alteration of downstream splice site position… vs Wild-type DHFR-TS locus
Design
Preclinical
Authors
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Cautions against assuming independent poly(A) selection in parasites; leaves open conservation of this coupling in other eukaryotes.
Demonstrates that poly(A) site selection in Leishmania is coupled to and specified by the position of the downstream splice acceptor.
LeBowitz et al. (1993) studied this question.
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