Population
Trypanosoma brucei (model organism)
Comparison
Mutagenesis of the intergenic region between the… vs Wild-type sequences
Design
Preclinical
Authors
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May inform trypanosome RNA biology but should not guide clinical practice; leaves open conservation of bifunctional pyrimidine elements in mammals.
Demonstrates that a common pyrimidine-rich motif governs both trans-splicing and polyadenylation in trypanosome tubulin pre-mRNA processing.
Matthews et al. (1994) studied this question.
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