Key result
Efficient use of the alpha-tubulin 3' splice site in Trypanosoma brucei depends on the presence of exon sequences, which modulate trans-splicing efficiency.
Population
Trypanosoma brucei (in vivo cis competition assay)
Comparison
Presence of exon sequences in the 5'… vs Minimal alpha-tubulin 3' splice site without…
Design
Preclinical
Authors
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Should not yet change clinical practice; leaves open whether exon sequences regulate trans-splicing in other eukaryotes.
Exon sequences in the 5' UTR of alpha-tubulin mRNA are required to positively regulate and modulate trans-splicing efficiency in Trypanosoma brucei.
López-Estraño et al. (1998) studied Trypanosoma brucei trans splicing. Exonic sequences in the 5' UTR of alpha-tubulin mRNA was evaluated on trans-splicing efficiency and accurate 3'-end formation. Efficient use of the alpha-tubulin 3' splice site in Trypanosoma brucei depends on the presence of exon sequences, which modulate trans-splicing efficiency.
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