Key result
Trypanosomes mature unspliced transcripts via trans-splicing uncoupled from transcription to potentially regulate gene expression.
Why the study?
Trypanosomes lack transcriptional gene expression control and rely on posttranscriptional regulation, but mechanisms of mRNA maturation and processing remain incompletely understood.
Comparison
Trans-splicing/polyadenylation sites processed vs skipped during polycistronic mRNA maturation
Design
Molecular biology study of mRNA processing in trypanosomes
Authors
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Identifies two-step mRNA maturation via splice-site skipping in trypanosomes; leaves open its prevalence and regulatory impact in kinetoplastids.
Jäger et al. (2007) studied Trypanosome gene expression. Trypanosomes can process unspliced transcripts into mature mRNAs by conventional trans-splicing/polyadenylation events uncoupled from transcription, potentially regulating gene expression.
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