Key result
Heat shock disrupted the processing machinery for tubulin mRNA precursors in Trypanosoma brucei, resulting in an accumulation of polycistronic RNA species.
Polycistronic transcripts are likely the precursors of monocistronic tubulin mRNAs in trypanosomes, as evidenced by their accumulation during heat shock.
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Hypothesis-generating for parasite RNA processing under stress; leaves open relevance to human trypanosomiasis or therapies.
Muhich et al. (1988) studied Trypanosoma brucei mRNA processing. Heat shock vs. Normal temperatures was evaluated on Accumulation of polycistronic RNA species and decrease in branched splicing intermediates. Heat shock disrupted the processing machinery for tubulin mRNA precursors in Trypanosoma brucei, resulting in an accumulation of polycistronic RNA species.
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