Key result
Synthesis of heat shock protein 70 (hsp 70) mRNA in T. brucei is resistant to heat-induced disruption of trans-splicing, maintaining the 5'-terminal mini-exon sequence.
Population
Trypanosoma brucei
Comparison
Severe heat shock vs Normal temperatures
Design
Preclinical
Authors
Loading...
Hypothesis-generating for parasite stress adaptation; leaves open therapeutic targeting of trans-splicing in trypanosomiasis.
T. brucei has evolved a mechanism that compensates for the deleterious effects of heat shock on trans-splicing, allowing continued synthesis of hsp70 mRNA.
Muhich et al. (1989) studied Trypanosoma brucei infection model. Severe heat shock vs. Normal temperatures was evaluated on Synthesis of hsp70 mRNA and presence of 5'-terminal mini-exon sequence. Synthesis of heat shock protein 70 (hsp 70) mRNA in T. brucei is resistant to heat-induced disruption of trans-splicing, maintaining the 5'-terminal mini-exon sequence.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: