Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists
Why the study?
Does thrombopoietin enhance human platelet aggregation induced by shear stress and multiple agonists?
Population
Human platelets in native plasma (hirudin platelet-rich plasma)
Comparison
Thrombopoietin (1 to 100 ng/mL) vs Absence of thrombopoietin or other cytokines
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May warrant prothrombotic monitoring in thrombopoietin use; leaves open human relevance from animal data.
Structured PICO
Does thrombopoietin enhance human platelet aggregation induced by shear stress and multiple agonists?
P
Population
Human platelets in native plasma (hirudin platelet-rich plasma)
I
Intervention
Thrombopoietin (1 to 100 ng/mL)
C
Comparator
Absence of thrombopoietin or other cytokines (IL-6, IL-11, IL-3, erythropoietin, G-CSF, GM-CSF, c-kit ligand)
O
Outcome
Platelet aggregation induced by shear stress and various agonists (ADP, epinephrine, collagen, thrombin, serotonin, vasopressin)surrogate
Thrombopoietin primes human platelets for aggregation induced by shear stress and multiple agonists, suggesting a potential prothrombotic effect that requires monitoring in clinical trials.
Cite This Study
Oda et al. (1996) studied this question.