Key result
Human recombinant thrombopoietin upregulated ADP-induced platelet aggregation and directly activated platelets by modulating intracellular signal transduction pathways, including Jak2 and Tyk2.
Population
Platelets in vitro
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for thrombopoietin effects on human platelet function.
Thrombopoietin directly activates platelets and modulates intracellular signal transduction pathways, upregulating aggregation induced by other agonists.
Kojima et al. (1995) studied Platelet activation. Human recombinant thrombopoietin (TPO) was evaluated on Platelet aggregation and signal transduction. Human recombinant thrombopoietin upregulated ADP-induced platelet aggregation and directly activated platelets by modulating intracellular signal transduction pathways, including Jak2 and Tyk2.
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