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December 15, 1998European Journal of Biochemistry

Thrombopoietin potentiates the protein‐kinase‐C‐mediated activation of mitogen‐activated protein kinase/ERK kinases and extracellular signal‐regulated kinases in human platelets

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Key result

Thrombopoietin synergizes with other agonists to potentiate the protein-kinase-C-mediated activation of the ERK pathway in human platelets.

Why the study?

Does thrombopoietin potentiate the ERK activation pathway in human platelets?

Population

Human platelets

Comparison

Thrombopoietin alone or in combination with… vs Agonists alone or no TPO

Design

Preclinical

Authors

YEYasuharu EzumiKyoto UniversityTUTakashi UchiyamaHigh Energy Accelerator Research OrganizationHTHiroshi TakayamaShinshu University

Discussion

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Implication

May modulate cytoskeletal over aggregatory platelet responses; leaves open clinical relevance in humans.

Structured PICO

Does thrombopoietin potentiate the ERK activation pathway in human platelets?

P
Population
Human platelets
I
Intervention
Thrombopoietin (TPO) alone or in combination with other agonists (thrombin, phorbol esters)
C
Comparator
Agonists alone (thrombin, phorbol esters) or no TPO
O
Outcome
Activation of the extracellular signal-regulated kinase (ERK) pathway (ERK1, ERK2, PKC, MEK1, MEK2, Raf-1)surrogate

Thrombopoietin synergizes with other agonists to potentiate the ERK activation pathway in human platelets, which may regulate cytoskeletal functions rather than primary aggregation.

Cite This Study

Ezumi et al. (1998) studied this question. Thrombopoietin (TPO) was evaluated on ERK activation pathway. Thrombopoietin synergizes with other agonists to potentiate the protein-kinase-C-mediated activation of the ERK pathway in human platelets.

synapsesocial.com/papers/6a96b5f1dc355c9d4e898261https://doi.org/10.1046/j.1432-1327.1998.2580976.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombopoietin Modulates Platelet Activation in Vitro through Protein‐Tyrosine Phosphorylation1996 · 46 citations
  2. 2Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation1996 · 65 citations
  3. 3Modulation of Platelet Activation In Vitro by Thrombopoietin1995 · 56 citations
  4. 4Thrombopoietin, c‐Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists‐induced aggregation in platelets in vitro1995 · 145 citations
  5. 5Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis1999 · 12 citations