May 15, 1996Biochemical JournalOpen Access

Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation

View Full Paper

Ask AI

Bookmark

Why the study?

Does Thrombopoietin potentiate activation of human platelets?

Population

Human platelets

Comparison

Thrombopoietin (TPO) vs Agonists alone without TPO

Design

Preclinical

Authors

BRB Rodriguez-LinaresJohn Radcliffe Hospital SWSteve P. WatsonVascular Medicine

Discussion

Member takes

Implication

TPO may prime platelets to offset thrombocytopenia; leaves open translation from animal models to human therapy.

Structured PICO

Does Thrombopoietin potentiate activation of human platelets?

Population

Human platelets

Intervention

Thrombopoietin (TPO)

Comparator

Agonists alone (thrombin, collagen, U46619) without TPO

Outcome

Platelet aggregation and dense-granule secretionsurrogate

Thrombopoietin primes human platelets for activation by other agonists, which may help compensate for reduced platelet density in thrombocytopenia.

Cite This Study

Rodriguez-Linares et al. (1996) studied this question.

synapsesocial.com/papers/6a97b0f5b677aa8bf5c609af https://doi.org/10.1042/bj3160093

View Full Paper

Ask AI

Bookmark

Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider