Key result
Cholesterol efflux capacity and HDL particle concentration were strong, inverse predictors of coronary endothelial dysfunction (P<0.001 and P=0.005, respectively), independent of HDL-C.
Why the study?
Do cholesterol efflux capacity and HDL particle concentration predict coronary endothelial dysfunction better than HDL-C in patients with nonobstructive coronary artery disease?
Population
80 subjects with nonobstructive (<30% stenosis) coronary artery disease
Design
Cross-sectional
Authors
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Impaired HDL function measures associate with coronary ED beyond HDL-C; hypothesis-generating for targeted HDL therapies.
Observational (n=80)
Do cholesterol efflux capacity and HDL particle concentration predict coronary endothelial dysfunction better than HDL-C in patients with nonobstructive coronary artery disease?
p-value: p=<0.001
Cholesterol efflux capacity and HDL particle concentration are better predictors of coronary endothelial dysfunction than traditional HDL-C levels, highlighting the importance of HDL function and size in early atherosclerosis.
Monette et al. (2016) conducted an observational in Nonobstructive coronary artery disease (n=80). Cholesterol efflux capacity and HDL particle concentration vs. HDL-cholesterol (HDL-C) was evaluated on Coronary endothelial dysfunction (ED) defined as <50% change in coronary blood flow in response to intracoronary acetylcholine (p=<0.001). Cholesterol efflux capacity and HDL particle concentration were strong, inverse predictors of coronary endothelial dysfunction (P<0.001 and P=0.005, respectively), independent of HDL-C.
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