Key result
Clopidogrel sulfate pretreatment reduced LPS-induced cytokines (IL-6 and TNF-α) and HMGB1 expression, and attenuated histological changes in lung and liver tissues in a rat model.
Why the study?
Does clopidogrel sulfate reduce LPS-induced systemic inflammation in a rat model?
Population
Male Wistar rats weighing 250 to 300 g in an LPS-induced systemic inflammation model
Comparison
Clopidogrel sulfate 10 mg/kg body weight oral… vs Oral dose of water given 5 days before LPS…
Design
Preclinical
Authors
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Offers preclinical support for clopidogrel in sepsis; hypothesis-generating and requires human trials before clinical consideration.
Does clopidogrel sulfate reduce LPS-induced systemic inflammation in a rat model?
Clopidogrel sulfate pretreatment attenuates LPS-induced systemic inflammation, cytokine release, and organ damage in a rat model of septic shock.
Hagiwara et al. (2010) studied LPS-induced systemic inflammation. Clopidogrel sulfate vs. Water was evaluated on Levels of proinflammatory markers (IL-6 and TNF-α) and HMGB1 expression. Clopidogrel sulfate pretreatment reduced LPS-induced cytokines (IL-6 and TNF-α) and HMGB1 expression, and attenuated histological changes in lung and liver tissues in a rat model.
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