Key result
Clopidogrel treatment significantly exacerbated inflammation in a rat model of PG-PS-induced arthritis, increasing the day 21 histopathological score to 16.56 compared to 10.17 with PG-PS alone.
Why the study?
Does clopidogrel potentiate the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis?
Population
48 female pathogen-free Lewis rats in a peptidoglycan polysaccharide-induced arthritis model.
Comparison
Clopidogrel 30 mg/kg daily oral dose in 0.5% CMC… vs PG-PS alone, clopidogrel alone, and untreated…
Design
Preclinical, Animals were randomly separated into 4 different groups
Follow-up
21 days
Authors
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May warrant caution with clopidogrel in inflammatory diseases; animal data leave open clinical relevance.
Does clopidogrel potentiate the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis?
Absolute Event Rate: 16.56% vs 10.17%
p-value: p=<0.05
Clopidogrel potentiates the inflammatory response in a rat model of PG-PS-induced arthritis, suggesting potential concerns for its use in patients with chronic inflammatory diseases.
Garcia et al. (2011) studied Peptidoglycan polysaccharide (PG-PS)-induced arthritis (n=48). Clopidogrel vs. PG-PS alone was evaluated on Histopathological score at day 21 (p=<0.05). Clopidogrel treatment significantly exacerbated inflammation in a rat model of PG-PS-induced arthritis, increasing the day 21 histopathological score to 16.56 compared to 10.17 with PG-PS alone.
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