January 1, 2005Thrombosis and Haemostasis

Clopidogrel inhibits platelet-leukocyte adhesion and plateletdependent leukocyte activation

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Why the study?

Does clopidogrel inhibit platelet-leukocyte adhesion and platelet-dependent leukocyte activation in mouse and human models?

Population

Mouse models (ex vivo) and isolated human cells or whole blood (in vitro)

Design

Preclinical

Authors

SMStefano ManariniUniversità Cattolica del Sacro Cuore NMNicola MartelliMario Negri Sud Foundation ENEmanuela NapoleoneCisco Systems (China)

Discussion

Member takes

Implication

Hypothesis-generating for clopidogrel's anti-inflammatory effects in atherosclerosis; human trials needed before clinical adoption.

Structured PICO

Does clopidogrel inhibit platelet-leukocyte adhesion and platelet-dependent leukocyte activation in mouse and human models?

Population

Mouse models (ex vivo) and isolated human cells or whole blood (in vitro)

Intervention

Clopidogrel or its active metabolite

Outcome

Platelet aggregation, P-selectin expression, platelet-PMN adhesion, ROS production, and tissue factor (TF) procoagulant activitysurrogate

Clopidogrel reduces platelet-dependent up-regulation of inflammatory and pro-atherothrombotic functions in leukocytes, which may help reduce inflammation underlying atherosclerosis.

Cite This Study

Manarini et al. (2005) studied this question.

synapsesocial.com/papers/6a7e3e4930b070d2738f45bb https://doi.org/10.1160/th05-01-0020

Topics

Dual antiplatelet therapy

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Clopidogrel inhibits platelet-leukocyte adhesion and plateletdependent leukocyte activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Clopidogrel inhibits platelet-leukocyte adhesion and plateletdependent leukocyte activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider