Why the study?
Does the Angiotensin II Type 1A receptor mediate the biphasic regulation of the Na+-HCO3- cotransporter by Angiotensin II in renal tubules?
Does the Angiotensin II Type 1A receptor mediate the biphasic regulation of the Na+-HCO3- cotransporter by Angiotensin II in renal tubules?
The study demonstrates that the AT1A receptor is responsible for the biphasic regulation of the Na+-HCO3- cotransporter by Angiotensin II.
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AT1A receptor mediates biphasic Ang II regulation of renal NBC in mice; confirms mechanism but leaves open human hypertension relevance.
Horita et al. (2002) studied this question.
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