Key result
Women with extensive coronary artery disease had 47% greater arteriolar wall thickness (P=0.012) and less interstitial fibrosis (P=0.019) compared to men.
Why the study?
Do myocardial structure and coronary microvasculature differ between men and women with coronary artery disease?
Population
57 patients with coronary artery disease undergoing coronary artery bypass graft surgery, without previous…
Comparison
Female sex (observational comparison) vs Male sex
Design
Cross-sectional
Authors
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May indicate greater ischemic vulnerability in women with CAD; hypothesis-generating for sex-specific microvascular research.
Observational (n=57)
Do myocardial structure and coronary microvasculature differ between men and women with coronary artery disease?
Effect estimate: 47% greater
p-value: p=0.012
Women with extensive CAD have greater arteriolar wall thickness and diffusion radius relative to body surface area compared to men, which may predispose them to myocardial ischemia.
Campbell et al. (2010) conducted an observational in Coronary artery disease (n=57). Female sex vs. Male sex was evaluated on Arteriolar wall area/circumference ratio (47% greater, p=0.012). Women with extensive coronary artery disease had 47% greater arteriolar wall thickness (P=0.012) and less interstitial fibrosis (P=0.019) compared to men.