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March 1, 1985Journal of Bone and Joint Surgery - British Volume

Dextran/aspirin versus heparin/dihydroergotamine in preventing thrombosis after hip fractures

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Why the study?

Does dextran/aspirin compared to heparin/dihydroergotamine reduce the incidence of deep venous thrombosis in patients undergoing surgery for fracture of the femoral neck?

Population

83 patients undergoing surgery for fracture of the femoral neck

Comparison

Dextran 40 peroperatively plus aspirin 0.5 g… vs Heparin calcium 5000 iu subcutaneously plus…

Design

RCT, randomised

Follow-up

10 days

Authors

MPM PiniUniversity of ParmaESE SpadiniUniversity of ParmaLCL Carluccio

Discussion

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Implication

Similar DVT rates support comparable efficacy of both regimens; confirms equivalence for prophylaxis in femoral neck fracture surgery.

Structured PICO

Does dextran/aspirin compared to heparin/dihydroergotamine reduce the incidence of deep venous thrombosis in patients undergoing surgery for fracture of the femoral neck?

P
Population
83 patients undergoing surgery for fracture of the femoral neck
I
Intervention
Dextran 40 peroperatively plus aspirin 0.5 g daily beginning before operation and continuing for 10 days after
C
Comparator
Heparin calcium 5000 iu subcutaneously plus dihydroergotamine 0.5 mg intramuscularly, given 8-hourly, beginning before operation and continuing for 10 days after
O
Outcome
Incidence of venographically established deep venous thrombosis (DVT)hard clinical

In patients undergoing surgery for femoral neck fracture, a heparin/dihydroergotamine regimen is preferable to dextran/aspirin as it is safer with fewer hemorrhagic complications and similarly effective in preventing DVT.

Cite This Study

Pini et al. (1985) studied this question.

synapsesocial.com/papers/6a7be089ef97a97562c62701https://doi.org/10.1302/0301-620x.67b2.2579953
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of deep vein thrombosis in patients with hip fractures: Low molecular weight heparin versus dextran1992 · 20 citations
  2. 2Clinical Efficacy of Aspirin and Dextran for Thromboprophylaxis in Geriatric Hip Fracture Patients1993 · 11 citations
  3. 3Apparent Lack of Synergism between Heparin and Dihydroergotamine in Prevention of Deep Vein Thrombosis after Elective Hip Replacement: a Randomised Double-Blind Trial Reported in Conjunction with an Overview of Previous Results1992 · 8 citations
  4. 4Heparin and dihydroergotamine prophylaxis against thrombo-embolism after hip arthroplasty1985 · 64 citations
  5. 5Prophylaxis for postoperative deep-vein thrombosis. Synergistic effect of heparin and dihydroergotamine1979 · 120 citations