Key result
Aspirin shows similar venous thromboembolism risk compared to dextran 40 in geriatric hip fracture patients.
Why the study?
The clinical efficacy, safety, and cost-effectiveness of aspirin versus dextran 40 for thromboprophylaxis in geriatric hip fracture patients were compared.
Does aspirin compared to dextran 40 prevent thromboembolic complications in geriatric hip fracture patients treated surgically?
Population
530 geriatric hip fracture patients treated surgically
Comparison
Aspirin vs dextran 40 for thromboprophylaxis
Design
Prospective review
Follow-up
Inhospital
Authors
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Supports aspirin or dextran 40 for VTE prophylaxis in geriatric hip fracture patients; observational data leaves open need for randomized confirmation.
Observational (n=530)
Does aspirin compared to dextran 40 prevent thromboembolic complications in geriatric hip fracture patients treated surgically?
Absolute Event Rate: 2.6% vs 2.4%
Aspirin and dextran 40 are equally effective for thromboprophylaxis in geriatric hip fracture patients, but aspirin is more cost-effective and has a lower postoperative transfusion rate.
Feldman et al. (1993) conducted an observational in geriatric hip fracture (n=530). Aspirin vs. Dextran 40 was evaluated on pulmonary embolism (PE). Aspirin and dextran 40 demonstrated similar efficacy for thromboprophylaxis in geriatric hip fracture patients, with PE occurring in 2.6% vs 2.4% and DVT in 0.5% vs 0.3%, respectively.
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