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April 1, 1988British journal of surgery

Dihydroergotamine and the thromboprophylactic effect of dextran 70 in emergency hip surgery

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Why the study?

Does the addition of dihydroergotamine to dextran 70 reduce postoperative thrombo-embolic complications in patients undergoing emergency hip surgery?

Population

45 consecutive patients with a fractured hip undergoing emergency hip surgery

Comparison

Dextran 70 and dihydroergotamine initiated… vs Dextran 70 alone initiated pre-operatively

Design

RCT, randomized

Follow-up

4 days postoperative

Authors

MRM Rørbæk-MadsenAarhus University HospitalBJBent Wulff JakobsenAleris Hamlet HospitalJPJannik Nedergaard PedersenAarhus University

Discussion

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Implication

Adding DHE to dextran 70 does not reduce postoperative DVT in emergency hip surgery; challenges combination prophylaxis and supports dextran 70 monotherapy.

Structured PICO

Does the addition of dihydroergotamine to dextran 70 reduce postoperative thrombo-embolic complications in patients undergoing emergency hip surgery?

P
Population
45 consecutive patients with a fractured hip undergoing emergency hip surgery
I
Intervention
Dextran 70 and dihydroergotamine (DHE) initiated pre-operatively
C
Comparator
Dextran 70 alone initiated pre-operatively
O
Outcome
Deep vein thrombosis (DVT) and/or pulmonary emboli detected by Tc-plasmin scintigraphy and pulmonary ventilation/perfusion scintigraphy on the first and fourth postoperative dayhard clinical

Adding dihydroergotamine to dextran 70 does not significantly reduce the incidence of postoperative DVT in emergency hip surgery compared to dextran 70 alone.

Cite This Study

Rørbæk-Madsen et al. (1988) studied this question.

synapsesocial.com/papers/6a87db9f02f504243ce9687dhttps://doi.org/10.1002/bjs.1800750423

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylaxis for postoperative deep-vein thrombosis. Synergistic effect of heparin and dihydroergotamine1979 · 120 citations
  2. 2Prophylaxis for Postoperative Deep-Vein Thrombosis1979 · 95 citations
  3. 3Deep vein thrombosis detection by 99mTc-plasmin test and phlebography1984 · 10 citations