What question did this study set out to answer?

To evaluate and compare the accuracy and precision of contemporary biosensors against standard enzymatic photometric procedures for measuring plasma lactate levels.

March 1, 2007Current GenomicsOpen Access

Nutrigenomics, β-Cell Function and Type 2 Diabetes

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To evaluate and compare the accuracy and precision of contemporary biosensors against standard enzymatic photometric procedures for measuring plasma lactate levels.
Tested contemporary biosensors (Chiron Diagnostics, Nova Biomedical) alongside standard enzymatic photometric assays (Sigma Diagnostics, Abbott Laboratories, Analyticon) in vitro.
Spiked fresh frozen plasma samples through stepwise additions of 1 molar sodium lactate solution to systematically generate concentrations up to 20 mmol/l.
Measurement precision across evaluated methods ranged between 1% and 7%, while overall accuracy ranged between 2% and -33%.
Variability was lowest in the Sigma photometric assay at 6%, compared to greater than 13% across both biosensor devices.
A true lactate level of 6 mmol/l registered between 4.4 and 7.6 mmol/l on biosensors, demonstrating paired determination discrepancies of several mmol/l.

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Implication

Laboratory comparative study reveals high variability in biosensor lactate measurements in plasma samples, highlighting substantial discrepancies with standard enzymatic photometry.

Cite This Study

Nino‐Fong et al. (2007) studied this question.

synapsesocial.com/papers/6a7be7ae2305edf9bbed29d0 https://doi.org/10.2174/138920207780076947

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Implication

Laboratory comparative study reveals high variability in biosensor lactate measurements in plasma samples, highlighting substantial discrepancies with standard enzymatic photometry.

Nutrigenomics, β-Cell Function and Type 2 Diabetes

Key Points

Discussion

Implication

Cite This Study

Nutrigenomics, β-Cell Function and Type 2 Diabetes

Key Points

Discussion

Implication

Cite This Study

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