Why the study?
Do circulating microRNAs (miR-3135b, miR-3908, miR-5571-5p) serve as diagnostic biomarkers for dilated cardiomyopathy?
Population
23 patients with dilated cardiomyopathy and 23 healthy controls
Comparison
Measurement of circulating plasma microRNAs vs Healthy controls
Design
Case-control
Authors
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Should not yet change DCM diagnostic practice; leaves open prospective validation before clinical adoption.
Do circulating microRNAs (miR-3135b, miR-3908, miR-5571-5p) serve as diagnostic biomarkers for dilated cardiomyopathy?
Circulating miR-3135b, miR-3908, and miR-5571-5p are significantly upregulated in DCM and may serve as novel diagnostic biomarkers, with miR-5571-5p correlating with disease severity.
Wang et al. (2016) studied this question.
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