Highlights a rare case of early cardiac involvement (large left ventricular mass) in a pediatric patient with precursor B-cell ALL and eosinophilia, leading to fatal cardiorespiratory failure.
Alerts clinicians to rapid deterioration risk in pediatric ALL with cardiac masses; hypothesis-generating for surveillance strategies in eosinophilia-associated cases.
Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. However, it may rarely associate with eosinophilia. Patients with ALL associated with eosinophilia (ALL/ Eo) have a grave prognosis and higher incidence of cardiac complications compared to standard lymphoblastic leukaemia. Reports of ALL/Eo disclosed a few case with cardiac involvement early in the course of leukaemia. Here, the authors report a case of 13-year-old boy who presented with peripheral eosinophilia, chest pain and a large left ventricular mass early in the course of precursor B- cell ALL associated with eosinophilia. He received multi-agent chemotherapy but succumbed to death 25 days after chemotherapy due to a refractory cardio respiratory failure.
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Gharabaghi et al. (2012) studied this question.
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