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June 25, 2025The MicrobeOpen Access

Current update on the antibiotic resistance profile and the emergence of colistin resistance in Enterobacter isolates from hospital-acquired infections

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Observational study reveals high multidrug resistance rates in clinical Enterobacter isolates, highlighting the emergence of colistin resistance.

Identify antimicrobial resistance patterns and evaluate the emergence of colistin resistance in Enterobacter species isolated from hospital-acquired infections.
Analyzed 51 clinical Enterobacter isolates (N=51) recovered from urine, pus, blood, cerebrospinal fluid, sputum, and stool at a tertiary center in Varanasi, India.
Identified species using VITEK-2 automated systems and species-specific PCR, performed whole genome sequencing on two isolates, and evaluated susceptibility using Kirby-Bauer disc diffusion and broth dilution minimum inhibitory concentration according to CLSI 2020 guidelines.
Resistance rates reached 94% for levofloxacin, 92% (47/51) for ciprofloxacin, 92% (47/51) for ampicillin, and 82% (42/51) for cefazolin.
Multiple antibiotic resistance index values exceeded 0.2 in 96.07% of isolates, with 21.56% demonstrating resistance to all tested antimicrobial agents.

Singh et al. (2025) studied this question.

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Observational study reveals high multidrug resistance rates in clinical Enterobacter isolates, highlighting the emergence of colistin resistance.