April 1, 1990Molecular and Cellular Biology
Postinduction Turnoff of Beta-Interferon Gene Expression
Population
Human beta-interferon (IFN-beta) gene expression model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not alter IFN therapy; leaves open whether these regulatory elements can be targeted in human disease.
Structured PICO
P
Population
Human beta-interferon (IFN-beta) gene expression model
I
Intervention
Viral induction and cycloheximide treatment
O
Outcome
Mechanism of postinduction decrease in IFN-beta mRNA levels
Demonstrates that postinduction turnoff of the human IFN-beta gene requires both synthesis of a virus-inducible repressor and specific mRNA destabilizing sequences.
Cite This Study
Whittemore et al. (1990) studied this question.