Inhibition of the Spontaneous Rate of Contraction of Neonatal Cardiac Myocytes by Protein Kinase C Isozymes

View Full Paper

Ask AI

Bookmark

Why the study?

Does 4-beta PMA reduce the rate of contraction in neonatal rat cardiac myocytes?

Population

Neonatal rat cardiac myocytes in culture

Design

Preclinical

Follow-up

1 hour

Authors

Discussion

Epsilon-PKC may suppress neonatal myocyte contraction rate; leaves open its role in human cardiac disease.

Does 4-beta PMA reduce the rate of contraction in neonatal rat cardiac myocytes?

Population

Neonatal rat cardiac myocytes in culture

Intervention

4-beta phorbol 12-myristate 13-acetate (4-beta PMA) at concentrations of 0.3 to 100 nmol/L

Outcome

Rate of contraction and distribution/levels of alpha-, beta-, delta-, epsilon-, and zeta-PKC isozymessurrogate

The epsilon-PKC isozyme appears to play a key role in suppressing the spontaneous contraction rate of neonatal rat cardiac myocytes.

Johnson et al. (1995) studied this question.

View Full Paper

Ask AI

Bookmark