Why the study?
Does the 19-mm Carpentier Edwards Perimount Magna bioprosthesis improve hemodynamics and left ventricular mass index regression compared to the 19-mm Medtronic Mosaic Ultra valve in patients with a small aortic annulus?
Does the 19-mm Carpentier Edwards Perimount Magna bioprosthesis improve hemodynamics and left ventricular mass index regression compared to the 19-mm Medtronic Mosaic Ultra valve in patients with a small aortic annulus?
The 19-mm Magna bioprosthesis provides satisfactory hemodynamics with lower LV-aortic pressure gradients than the Mosaic valve, though both yield similar LV mass index regression regardless of prosthesis-patient mismatch.
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Similar LV mass regression despite lower gradients with Magna should not yet change valve choice; leaves open whether hemodynamics affect long-term outcomes in small annuli.
Okamura et al. (2011) studied this question.
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