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October 1, 2001Shock

Uncoupling and Recoupling of Autonomic Regulation of the Heart Beat in Pediatric Septic Shock

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Population

7 children with septic shock hospitalized in the pediatric intensive care unit (PICU)

Comparison

Serial monitoring of heart rate variability… vs Initial 24 hours of PICU hospitalization versus…

Design

Case_series

Follow-up

Duration of PICU hospitalization

Authors

MEMiles S. EllenbyPortland State UniversityJMJames McNamesClarion UniversitySLSusanna LaiOregon Health & Science University

Discussion

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Implication

HRV shifts in this single pediatric septic shock case are hypothesis-generating; larger studies needed before any clinical role.

Structured PICO

P
Population
7 children with septic shock hospitalized in the pediatric intensive care unit (PICU)
I
Intervention
Serial monitoring of heart rate variability metrics at 6-hour intervals
C
Comparator
Initial 24 hours of PICU hospitalization versus the remainder of the PICU stay (for patients with stay > 48 h)
O
Outcome
Serial changes in heart rate variability metrics (low-frequency power, high-frequency power, low-/high-frequency ratio)surrogate

Monitoring heart rate variability metrics in pediatric septic shock reveals an uncoupling and recoupling phenomenon, with increasing low-frequency power and decreasing high-frequency power over time.

Cite This Study

Ellenby et al. (2001) studied this question.

synapsesocial.com/papers/6a7c2372169fe1af7cc2a76dhttps://doi.org/10.1097/00024382-200116040-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decomplexification in critical illness and injury: Relationship between heart rate variability, severity of illness, and outcome1998 · 186 citations
  2. 2Linear and nonlinear analysis of hemodynamic signals during sepsis and septic shock2000 · 74 citations
  3. 3Autonomic Nervous System Dysfunction Is Associated With Re-hospitalization in Pediatric Septic Shock Survivors2022 · 9 citations
  4. 4Disruption of Brain–Heart Coupling in Sepsis2017 · 15 citations
  5. 5Cutoff Values of Hemodynamic Parameters in Pediatric Refractory Septic Shock2022 · 3 citations