Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1993Nucleic Acids ResearchOpen Access

Interaction of proteins with the mRNA for ribosomal protein L1 inXenopus: structural characterization ofin vivocomplexes and identification of proteins that bindin vivoto its 5’UTR

View Full Paper
Ask AI
Bookmark
Share

Population

Xenopus r-protein mRNAs (specifically L1 mRNA)

Comparison

In vitro RNA/protein complex formation analysis… vs Unrelated RNAs

Design

Preclinical

Authors

BCBeatrice CardinaliInstitute of Cell Biology and NeurobiologyMCManlio Di CristinaUniversity of PerugiaPPPaola Pierandrei‐AmaldiUniversity of Rome Tor Vergata

Discussion

Loading...

Member takes

Implication

No immediate clinical implications; leaves open whether these 5'UTR-binding proteins regulate rp-mRNA translation in mammals.

Structured PICO

P
Population
Xenopus r-protein mRNAs (specifically L1 mRNA)
I
Intervention
In vitro RNA/protein complex formation analysis focusing on the 5'UTR
C
Comparator
Unrelated RNAs
O
Outcome
Identification of proteins binding to the 5'UTR of L1 mRNA and structural characterization of in vivo complexessurrogate

Identified specific proteins that bind to the 5'UTR of Xenopus ribosomal protein L1 mRNA, which may be involved in its translational regulation.

Limitations

  • Involvement of these proteins in translation regulation remains to be proved

Cite This Study

Cardinali et al. (1993) studied this question.

synapsesocial.com/papers/6a7c2f72d501feb4353bdcf4https://doi.org/10.1093/nar/21.10.2301
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation.1992 · 95 citations
  2. 2Efficient<i>in vitro</i>synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter1984 · 6,458 citations
  3. 3Developmental expression and 5S rRNA-binding activity of Xenopus laevis ribosomal protein L5.1989 · 56 citations
  4. 4Functional messenger RNAs are produced by SP6<i>in vitro</i>transcription of cloned cDNAs1984 · 1,550 citations
  5. 5Characterization of the Multigene Family Encoding the Mouse S16 Ribosomal Protein: Strategy for Distinguishing an Expressed Gene from Its Processed Pseudogene Counterparts by an Analysis of Total Genomic DNA1985 · 59 citations