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January 1, 1992Journal of Biological ChemistryOpen Access

A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation.

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Population

Murine 3T3 fibroblasts and quiescent T-lymphocytes

Comparison

Plasmid containing murine L32 cDNA under RSV… vs Endogenous L32 mRNA; RNA probes lacking…

Design

Preclinical

Authors

RKRoger L. KasparBrigham Young UniversityTKTomohito KakegawaChiba UniversityHCHarwood J. CranstonMontana State University

Discussion

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Implication

May inform translational control studies in cardiomyocytes; leaves open relevance to human cardiovascular disease.

Structured PICO

P
Population
Murine 3T3 fibroblasts and quiescent T-lymphocytes
I
Intervention
Plasmid containing murine L32 cDNA under RSV promoter; deletion of polypyrimidine region
C
Comparator
Endogenous L32 mRNA; RNA probes lacking polypyrimidine sequence
O
Outcome
mRNA redistribution from subribosomal particles into polysomes and binding of a 56-kDa proteinsurrogate

Identifies a conserved 5' polypyrimidine region and a specific 56-kDa binding protein essential for the mitogenic translational regulation of ribosomal protein L32 mRNA.

Cite This Study

Kaspar et al. (1992) studied this question.

synapsesocial.com/papers/6a7c2f72d501feb4353bdcf6https://doi.org/10.1016/s0021-9258(18)48524-9
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional analysis of the internal translation initiation site of foot-and-mouth disease virus1990 · 203 citations
  2. 2Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei1983 · 11,637 citations
  3. 3Regulation of protein synthesis in mitogen-activated bovine lymphocytes. Analysis of actin-specific and total mRNA accumulation and utilization.1983 · 160 citations
  4. 4Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.1991 · 357 citations