Why the study?
Does pretreatment with heparin or N-acetyl heparin reduce ischemia/reperfusion injury in isolated rabbit hearts?
Does pretreatment with heparin or N-acetyl heparin reduce ischemia/reperfusion injury in isolated rabbit hearts?
Heparin and its non-anticoagulant derivative N-acetyl heparin protect the myocardium from ischemia/reperfusion injury independent of antithrombin mechanisms.
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May protect rabbit myocardium from I/R injury; hypothesis-generating for clinical cardioprotection.
Friedrichs et al. (1994) studied this question.
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