July 1, 1996

Reduction of Myocardial Necrosis After Glycosaminoglycan Administration: Effects of a Single Intravenous Administration of Heparin or N-Acetylheparin 2 Hours Before Regional Ischemia and Reperfusion.

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Why the study?

Does pretreatment with heparin or N-acetylheparin reduce myocardial infarct size in a canine model of ischemia and reperfusion?

Structured PICO

Does pretreatment with heparin or N-acetylheparin reduce myocardial infarct size in a canine model of ischemia and reperfusion?

Population

Anesthetized canines subjected to 90-minute occlusion of the left circumflex coronary artery (LCX) and 6 hours of reperfusion, with ischemic zone regional blood flow < 0.16 mL/min/g tissue.

Intervention

Heparin (2 mg/kg) or N-acetylheparin (2 mg/kg) administered intravenously as a single dose 2 hours before LCX occlusion.

Comparator

Vehicle (0.9% sodium chloride) administered intravenously 2 hours before LCX occlusion.

Outcome

Infarct size as a percentage of the left ventricular area at risk.surrogate

Pretreatment with heparin or N-acetylheparin significantly reduces myocardial infarct size in a canine model of ischemia-reperfusion injury, independent of anticoagulant effects.

Discussion

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Implication

Does not alter clinical practice; leaves open translation of heparin-mediated cardioprotection from canine ischemia-reperfusion to humans.

Cite This Study

Gralinski et al. (1996) studied this question.

synapsesocial.com/papers/6a983f16f4ab474a3623b8bf https://doi.org/10.1177/107424849600100305

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Implication

Does not alter clinical practice; leaves open translation of heparin-mediated cardioprotection from canine ischemia-reperfusion to humans.

Reduction of Myocardial Necrosis After Glycosaminoglycan Administration: Effects of a Single Intravenous Administration of Heparin or N-Acetylheparin 2 Hours Before Regional Ischemia and Reperfusion.

Structured PICO

Discussion

Implication

Cite This Study

Reduction of Myocardial Necrosis After Glycosaminoglycan Administration: Effects of a Single Intravenous Administration of Heparin or N-Acetylheparin 2 Hours Before Regional Ischemia and Reperfusion.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider