Key result
Depression symptoms significantly increased the risk of major adverse cardiovascular events (HR 2.30) in coronary artery disease patients experiencing chest pain more than once per week.
Why the study?
Does chest pain frequency influence the prognostic value of depression and anxiety for cardiovascular outcomes in patients with coronary artery disease?
Comparison
Influence of chest pain frequency and course on mood symptoms and prognosis
Design
Secondary analysis of a cross-sectional study with prospective prognostic monitoring
Follow-up
Median 26 months
Authors
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Depression screening may identify higher MACE risk in frequent-angina CAD; hypothesis-generating and requires prospective trials before practice change.
Cross-Sectional (n=561)
No
Does chest pain frequency influence the prognostic value of depression and anxiety for cardiovascular outcomes in patients with coronary artery disease?
Hazard Ratio: 2.3 (95% CI 1.12–4.72)
p-value: p=0.023
Chest pain frequency is a crucial determinant of mood symptoms in CAD patients and significantly modifies the prognostic value of depression and anxiety for adverse cardiovascular outcomes.
Tan et al. (2023) conducted a cross-sectional in Coronary artery disease (n=561). Depression symptoms in patients with frequent chest pain (>1 time/week) vs. Patients without depression symptoms was evaluated on Major adverse cardiovascular events (MACE) (HR 2.30, 95% CI 1.12-4.72, p=0.023). Depression symptoms significantly increased the risk of major adverse cardiovascular events (HR 2.30) in coronary artery disease patients experiencing chest pain more than once per week.
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