Key result
Depression symptoms predict ~170% higher MACE risk post-PCI, while anxiety adds no predictive value.
Why the study?
Depression and anxiety often co-occur in CAD patients undergoing PCI, but their individual and combined predictive value on prognosis in Chinese PCI patients required examination.
Do depression and anxiety symptoms predict major adverse cardiovascular events in Chinese patients after primary PCI?
Cohort (n=309)
Yes
Do depression and anxiety symptoms predict major adverse cardiovascular events in Chinese patients after primary PCI?
Hazard Ratio: 2.7 (95% CI 1.22–5.95)
p-value: p=0.014
Depression and anxiety independently predict 12-month MACE following primary PCI, highlighting the prognostic importance of psychosocial screening in this population.
Supports depression assessment post-PCI; leaves open whether screening or treatment alters MACE risk.
Depression and anxiety often co-occur in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). This study was conducted to examine the predictive value of depression, anxiety, and their combination on the prognosis of Chinese PCI patients. A multicenter prospective study was undertaken with a sample of 309 primary PCI patients. The Hospital Anxiety and Depression Scale (HADS) was completed at baseline to assess anxiety and depression symptoms. Major adverse cardiovascular events (MACEs) were recorded for 12 months after PCI . Days from baseline to the first MACE was the outcome variable. MACEs occurred in 26 (8.4%) patients. After adjustments for socio-demographic and clinical characteristics, a Cox proportional hazards regression model revealed that depression (HR = 2.70, 95% confidence interval [CI] 1.22–5.95; p =.014) and anxiety (HR = 2.56, 95% CI 1.18–5.54; p =.017) symptoms were independent predictors of MACEs. A subanalysis showed that the cumulative event-free survival curves did not differ among depressed and anxious patients and depressed but non-anxious patients (Log Rank p =.52). In conclusion, depression is associated with an increased risk for MACEs post-PCI, independent of anxiety. Although anxiety is associated with MACEs, it has no additional predictive value when co-occurring with depression.
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Hou et al. (2020) conducted a cohort in Coronary artery disease undergoing primary percutaneous coronary intervention (n=309). Depression symptoms vs. Absence of depression symptoms was evaluated on Major adverse cardiovascular events (MACEs) (HR 2.70, 95% CI 1.22-5.95, p=0.014). Depression symptoms independently predicted major adverse cardiovascular events in patients post-PCI (HR 2.70; 95% CI 1.22-5.95; p=0.014), whereas anxiety provided no additional predictive value.
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