Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1981Journal of Biological ChemistryOpen Access

Heparin-releasable and nonreleasable lipoprotein lipase in the perfused rat heart.

View Full Paper
Ask AI
Bookmark
Share

Population

Perfused rat heart model

Comparison

30-s perfusion with heparin vs Lipase remaining in the heart tissue ('residue')

Design

Preclinical

Authors

OBOsnat Ben-ZeevWest Los Angeles CollegeHSHerzl SchwalbHadassah Medical CenterMSMichael C. SchotzOtsuka (Japan)

Discussion

Loading...

Member takes

Implication

Distinct cardiac LPL pools in rats; leaves open precursor hypothesis for human endothelial regulation.

Structured PICO

P
Population
Perfused rat heart model
I
Intervention
30-s perfusion with heparin
C
Comparator
Lipase remaining in the heart tissue ('residue')
O
Outcome
Enzymatic properties of lipoprotein lipase (Km values for triglyceride, immunotitration curves, and response to heparin)surrogate

The rat heart contains a less active, low-affinity form of lipoprotein lipase in the tissue, which may represent a precursor to the high-affinity, functional, endothelial-bound form.

Cite This Study

Ben-Zeev et al. (1981) studied this question.

synapsesocial.com/papers/6a7c3a2dd51985d5a1c2a082https://doi.org/10.1016/s0021-9258(19)68657-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation, molecular properties, and kinetic characterization of lipoprotein lipase from rat heart.1977 · 86 citations
  2. 2A stable, radioactive substrate emulsion for assay of lipoprotein lipase1976 · 841 citations
  3. 3Studies on Release of Lipoprotein Lipase Activity from Fat Cells1971 · 57 citations
  4. 4Coupling of glycosaminoglycans to agarose beads (Sepharose 4B)1971 · 317 citations