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January 1, 1970Journal of Lipid ResearchOpen Access

Influence of heparin on the removal of serum lipoprotein lipase by the perfused liver of the rat

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Population

Isolated rat livers perfused with whole rat blood containing postheparin lipoprotein lipase (LPL) activity

Comparison

Addition of heparin to the perfusate or to the… vs Control experiments without heparin addition

Design

Preclinical

Authors

CNChikayuki NAITOTeikyo University HospitalJFJames M. FeltsSan Francisco VA Medical Center

Discussion

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Implication

Heparin may inhibit hepatic LPL clearance in this rat model; leaves open relevance to human lipoprotein metabolism.

Structured PICO

P
Population
Isolated rat livers perfused with whole rat blood containing postheparin lipoprotein lipase (LPL) activity
I
Intervention
Addition of heparin to the perfusate (4 units/ml) or to the LPL assay system
C
Comparator
Control experiments without heparin addition
O
Outcome
Disappearance of LPL activity from the perfusate (extraction ratio)surrogate

Heparin blocks the hepatic removal of lipoprotein lipase in a perfused rat liver model, suggesting a two-step inactivation system for LPL by the liver.

Cite This Study

NAITO et al. (1970) studied this question.

synapsesocial.com/papers/6a71307af44fa9f079def846https://doi.org/10.1016/s0022-2275(20)43016-0
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Also Consider

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  1. 1Serum requirement for release of heparin-induced lipase from perfused rat heart1964 · 14 citations