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December 1, 1970Circulation Research

Activation of Lipoprotein Lipase

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Population

Guinea pig post-heparin serum (deficient in HDL) and rat serum lipoprotein fractions

Comparison

Addition of rat serum lipoprotein fractions with… vs Guinea pig post-heparin serum alone or with…

Design

Preclinical

Authors

TWThomas F. WhayneUniversity of KentuckyJFJames M. FeltsSan Francisco VA Medical Center

Discussion

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Implication

Heparin may allosterically modify LPL; animal kinetics leave open effects on human triglyceride metabolism.

Structured PICO

P
Population
Guinea pig post-heparin serum (deficient in HDL) and rat serum lipoprotein fractions
I
Intervention
Addition of rat serum lipoprotein fractions (HDL, VLDL, LDL) with or without heparin
C
Comparator
Guinea pig post-heparin serum alone or with different fractions/concentrations
O
Outcome
Rate of triglyceride (TG) emulsion hydrolysissurrogate

Heparin may function as an allosteric modifier of lipoprotein lipase, altering its interaction kinetics with triglyceride substrates.

Cite This Study

Whayne et al. (1970) studied this question.

synapsesocial.com/papers/6a70e36ae71d69abee08ec28https://doi.org/10.1161/01.res.27.6.941
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of heparin on the removal of serum lipoprotein lipase by the perfused liver of the rat1970 · 13 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,692 citations
  3. 3Structural Studies of Rat Plasma Lipoproteins*1967 · 64 citations
  4. 4Titration of free fatty acids of plasma: a study of current methods and a new modification1960 · 1,022 citations
  5. 5Electrophoretic separation of plasma lipoproteins in agarose gel1968 · 1,312 citations