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March 1, 1964American Journal of Physiology-Legacy Content

Serum requirement for release of heparin-induced lipase from perfused rat heart

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Why the study?

Does the addition of heparin and serum to the perfusion medium increase the release of lipolytic enzyme in isolated perfused rat hearts?

Population

Isolated perfused rat heart

Comparison

Perfusion medium with heparin and/or serum vs Perfusion medium without heparin and/or serum

Design

Preclinical

Authors

MCM. F. CrassTexas Tech UniversityHMH. C. MengHebei Medical University

Discussion

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Implication

Highlights heparin-serum requirements for lipase release in rat heart models; leaves clinical translation open.

Structured PICO

Does the addition of heparin and serum to the perfusion medium increase the release of lipolytic enzyme in isolated perfused rat hearts?

P
Population
Isolated perfused rat heart
I
Intervention
Perfusion medium (Krebs-Henseleit bicarbonate buffer, pH 7.4) with heparin and/or serum
C
Comparator
Perfusion medium without heparin and/or serum
O
Outcome
Release of lipolytic enzyme (lipolytic activity of perfusates)surrogate

Both heparin and serum are required for the optimal release of heparin-induced lipase from the perfused rat heart.

Cite This Study

Crass et al. (1964) studied this question.

synapsesocial.com/papers/6a84f7c4abaf849ca59deb7fhttps://doi.org/10.1152/ajplegacy.1964.206.3.610

Topics

Sermorelin
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heparin-releasable and nonreleasable lipoprotein lipase in the perfused rat heart.1981 · 36 citations
  2. 2Influence of heparin on the removal of serum lipoprotein lipase by the perfused liver of the rat1970 · 13 citations
  3. 3Instability of endothelium-bound lipoprotein lipase activity in perfused rat hearts1984 · 2 citations
  4. 4Activation of Lipoprotein Lipase1970 · 33 citations
  5. 5Hydrolysis of Rat Chylomicron, Human Very Low Density Lipoprotein by Rat Heart Lipoprotein Lipase and Inhibition of Activity by Low Density Lipoprotein Chelesterol1979