Key result
Higher mean systolic blood pressure and wider pulse pressure were positively correlated with increased carotid intima-media thickness in very elderly Japanese patients (P=.012 and P=.018, respectively).
Why the study?
Are systolic blood pressure and pulse pressure associated with increased carotid intima-media thickness in high-risk elderly Japanese patients?
Observational (n=240)
Are systolic blood pressure and pulse pressure associated with increased carotid intima-media thickness in high-risk elderly Japanese patients?
High systolic blood pressure and wide pulse pressure remain significant determinants of increased carotid intima-media thickness even in very elderly patients.
Supports BP monitoring in very elderly vascular assessment; extends associations but leaves open whether lowering alters cIMT progression.
Many studies have demonstrated that increased carotid intima-media thickness (IMT) is related to future cardiovascular events and is influenced by cardiovascular risk factors such as sex, hypertension, diabetes, and hypercholesterolemia. Although aging is a well-known risk factor for an increase in carotid IMT, few studies have investigated which factors influence carotid IMT in the very elderly. In the present study, we investigated the relationship of pulse pressure (PP), blood pressure (BP), and its variability (six consecutive visits) with carotid IMT among 240 high-risk elderly in whom risk factors were managed clinically (average age was 79 ± 5 years). In the simple correlation, mean systolic BP (SBP) had a positive correlation with IMT and max IMT (P = .012 and P = .045), as did PP (P = .018 and P = .004), but did not diastolic BP or standard deviation of BP and coefficient of variation of BP. In multiple regression analyses, mean SBP and mean PP were each determinants of both IMT and max IMT, when each parameter was added separately to the regression model. We concluded that high SBP and wide PP still have an influence on increased carotid IMT in the very elderly Japanese patients.
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Oishi et al. (2013) conducted an observational in High cardiovascular risk (n=240). Systolic blood pressure and pulse pressure was evaluated on Carotid intima-media thickness (IMT) and max IMT (p=.012). Higher mean systolic blood pressure and wider pulse pressure were positively correlated with increased carotid intima-media thickness in very elderly Japanese patients (P=.012 and P=.018, respectively).
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