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January 1, 2001Journal of General Virology

Molecular strategy for ‘serotyping’ of human enteroviruses

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Population

59 of 64 prototype strains and 45 field isolates of human enteroviruses

Comparison

Molecular typing method based on RT-PCR and… vs Standard immunological techniques and database…

Design

Preclinical

Authors

VCValérie CaroInstitut PasteurSGSophie GuillotCentre National de la Recherche ScientifiqueFDFrançis DelpeyrouxCentre National de la Recherche Scientifique

Discussion

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Overview

Supports VP1-based enterovirus typing in research; leaves open clinical translation pending human validation.

Structured PICO

P
Population
59 of 64 prototype strains and 45 field isolates of human enteroviruses (involving 21 serotypes and 6 strains untypable by standard immunological techniques)
I
Intervention
Molecular typing method based on RT-PCR and sequencing of a 1452 bp genomic fragment including the 3' end of the VP1-coding region
C
Comparator
Standard immunological techniques and database sequences
O
Outcome
Nucleotide identity score and phylogenetic relationshipssurrogate

The 3' third of the VP1-coding sequence contains serotype-specific information and can be used for effective and rapid molecular typing of human enteroviruses.

Cite This Study

Caro et al. (2001) studied this question.

synapsesocial.com/papers/6a7c4bae24f98b6d3fc2c5e2https://doi.org/10.1099/0022-1317-82-1-79
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Also Consider

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  1. 1A distinct picornavirus group identified by sequence analysis.1992 · 278 citations
  2. 2Genetic and phylogenetic clustering of enteroviruses1996 · 189 citations
  3. 3Molecular evolution of swine vesicular disease virus.1999 · 89 citations
  4. 4Classification of enteroviruses based on molecular and biological properties.1997 · 274 citations
  5. 5Enteroviral Infections of the Central Nervous System1995 · 314 citations