Homotypic echoviruses share aminoterminal VP1 sequence homology applicable for typing

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Population

133 echovirus sequences

Design

Preclinical

Authors

Discussion

May support VP1 sequencing for echovirus typing in research; leaves open clinical adoption pending human validation.

Population

133 echovirus sequences (28 echovirus prototypes, 61 clinical isolates, and 39 sequences retrieved from GenBank)

Intervention

Sequencing 570 nucleotides from the 5'-end of the VP1 region of the genome

Outcome

Concordance between the sequences of the region encoding the VP1 aminoterminus and the serotypesurrogate

Sequence analysis of the VP1 aminoterminus region can correctly classify echovirus isolates and complement typing by neutralization.

Norder et al. (2000) studied this question.

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